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4-Nitrobenzenesulfonyl chloride, 97%, Thermo Scientific Chemicals Product Code.: 11418427
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4-Nitrobenzenesulfonyl chloride, 97%, Thermo Scientific Chemicals

Product Code. 11418427
25 g
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Product Code. 11418427

Brand: Thermo Scientific Alfa Aesar A18512.14

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Description

4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2'-bipyridine, nbs = 4-nitrobenzenesulfonate).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2′-bipyridine, nbs = 4-nitrobenzenesulfonate).

Solubility
Soluble in toluene, tetrahydrofuran, methylene chloride and ethyl acetate. Insoluble in water.

Notes
Moisture sensitive. Incompatible with strong oxidizing agents and strong bases.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 98-74-8
Molecular Formula C6H4ClNO4S
Molecular Weight (g/mol) 221.61
MDL Number MFCD00007445
InChI Key JXRGUPLJCCDGKG-UHFFFAOYSA-N
Synonym 4-nitrobenzenesulfonylchloride, 4-nitrobenzene-1-sulfonyl chloride, benzenesulfonyl chloride, 4-nitro, 4-nitrobenzenesulphonyl chloride, 4-nitrophenylsulfonyl chloride, p-nitrophenylsulfonyl chloride, 4-nitrobenzenesulfonic acid chloride, p-nitrobenzenesulfonyl chloride, 4-nitrobenzenesulphonylchloride, 4-nitro-benzenesulfonyl chlorideShow MoreShow Less
PubChem CID 7404
SMILES [O-][N+](=O)C1=CC=C(C=C1)S(Cl)(=O)=O

Specifications

Melting Point 76°C to 80°C
Boiling Point 143°C to 144°C (1.5 mmHg)
Quantity 25 g
UN Number UN3261
Beilstein 746543
Sensitivity Moisture sensitive
Solubility Information Soluble in toluene,tetrahydrofuran,methylene chloride and ethyl acetate. Insoluble in water.
IUPAC Name 4-nitrobenzenesulfonyl chloride
Formula Weight 221.62
Percent Purity 97%
Chemical Name or Material 4-Nitrobenzenesulfonyl chloride
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5 results found
Lot Number Certificate Type Date Catalog Number
Lot Number10223005 Certificate TypeCertificate of Analysis Date30/08/2024 Catalog NumberA18512.22,A18512.14,A18512.36
Lot Number10138125 Certificate TypeCertificate of Analysis Date05/12/2023 Catalog NumberA18512.22,A18512.14,A18512.36
Lot NumberJ6506A Certificate TypeCertificate of Analysis Date23/11/2021 Catalog NumberA18512.22,A18512.14,A18512.36
Lot NumberF2886A Certificate TypeCertificate of Analysis Date23/11/2021 Catalog NumberA18512.22,A18512.14,A18512.36
Lot NumberH8575A Certificate TypeCertificate of Analysis Date23/11/2021 Catalog NumberA18512.22,A18512.14,A18512.36

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