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5-Fluorouracil, 99%, Thermo Scientific Chemicals
Description
5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.
Notes
Store in a cool place. Incompatible with strong oxidizing agents and strong bases.
Specifications
Specifications
| Melting Point | ∼282°C (decomposition) |
| Assay Percent Range | 99% |
| Quantity | 25 g |
| UN Number | UN2811 |
| Beilstein | 127172 |
| Sensitivity | Light sensitive |
| Merck Index | 14,4181 |
| Solubility Information | Soluble in dimethylformamide,dimethyl sulfoxide,methanol,hot water,ammonium hydroxide,sodium hydroxide,ethanol and water. |
| Formula Weight | 130.08 |
| Percent Purity | 99% |
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Safety and Handling
- 5-Fluorouracil
- Danger
- Acute toxicity Category 3
- Acute toxicity Category 4
- Serious eye damage/eye irritation Category 2
- Germ cell mutagenicity Category 2
- Reproductive toxicity Category 2
- Skin corrosion/irritation Category 2
- Specific target organ toxicity Category 3
- H301-Toxic if swallowed.
- H312-Harmful in contact with skin.
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- H332-Harmful if inhaled.
- H335-May cause respiratory irritation.
- H341-Suspected of causing genetic defects.
- H361d-Suspected of damaging the unborn child.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P332+P313-If skin irritation occurs: Get medical advice/attention.
- P337+P313-If eye irritation persists: Get medical advice/attention.
- MIXTURE LIST-Contains : Fluorouracil
RUO – Research Use Only