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Invitrogen™ Active/Pro-Caspase 3 Monoclonal Antibody (31A1067)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA191637
This item is not returnable.
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Description
Predicted molecular weight: 31kDa. Positive Control: Staurosporine-treated HeLa or Jurkat cell lysate.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Specifications
| Active/Pro-Caspase 3 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.05% sodium azide | |
| P42574, P55213, P70677, Q95ND5 | |
| CASP3 | |
| Full-length recombinant human caspase-3 protein was used as immunogen. The antibody recognizes an epitope in the large domain subunit of Caspase-3. As such it will recognize pro Caspase-3 and the large subunit cleavage fragment. | |
| 100 μg | |
| Primary | |
| Hamster, Human, Mouse, Pig, Rat | |
| Antibody | |
| IgG1 |
| Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunomicroscopy, Western Blot, Immunocytochemistry, Mass Spectrometry | |
| 31A1067 | |
| Unconjugated | |
| CASP3 | |
| A830040C14Rik; AC-3; Apopain; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; CC3; Cpp32; CPP-32; CPP32B; CPP32beta; cysteine protease CPP32; IRP; Lice; mldy; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein | |
| Mouse | |
| Protein G | |
| RUO | |
| 100689061, 12367, 25402, 397244, 836 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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