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Tim23 Mouse, Unlabeled, Clone: 32, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 611223

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Product Code. 15805849

  • 442.00 EUR / 1 set

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Description

Description

Mitochondria, the site of cellular energy production, must import all proteins necessary for their function. Import is mediated by two mechanisms: the translocase of the outer membrane (Tom) and the translocase of the inner membrane (Tim). Tim23 and Tim17 are integral membrane proteins that associate to form the import channel for mitochondrial preproteins that contain N-terminal hydrophilic sequences. They also associate with Tim44, an adaptor for the membrane binding of mtHsp70, a matrix heat shock protein, which drives the import of the
processed preprotein. The N-terminal intermembrane space domain of Tim23 contains a leucine zipper motif and mediates the formation of a Tim23 dimer. As an imported protein passes through the TOM machinery, its N-terminal matrix targeting sequence interacts with the Tim23 dimer. This induces the dissociation of the dimer and initiation of inner membrane translocation of the presequence. In addition to its 9kDa N-terminal hydrophilic segment, Tim23 contains a 14kDa hydrophobic domain with four predicted membrane spans. Thus, Tim23 is an important integral membrane component of the mitochondrial protein translocation machinery.

Host Species: Mouse
Clone: 32
Isotype: IgG2a
Species Reactivity: Mouse
Immunogen: Rat Tim23 aa. 5-126
Formula Weight [Chemical]: 23kDa

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Tim23
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Rat Tim23 aa. 5-126
150 μg
Cell Biology
Human, Mouse, Rat
IgG2a
Western Blot
32
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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