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AX 15836, > 98%, Tocris Bioscience™

Product Code. 30002071
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Quantity:
10 mg
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Description

Potent and selective ERK5 inhibitor

Potent and selective ERK5 inhibitor (IC50 = 8 nM). Exhibits >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (Kd = 3,600 nM). Increases vomocytosis in human macrophages in vitro, as well as in an in vivo zebrafish model of cryptococcal disease, reducing spread of infection.

Specifications

CAS 2035509-96-5
Molecular Formula C32H40N8O5S
Linear Formula C32H40N8O5S
Quantity 10 mg
Synonym 5,11-dihydro-2-2-ethoxy-4-4-4-methyl-1-piperazinyl-1-piperidinyl carbonyl phenyl amino-5-methyl,11-methylsulfonyl-6h-pyrimido 4,5-b 1,4 benzodiazepin-6-one
Solubility Information Soluble to 100mM in 1eq. HCl and to 100mM in DMSO
InChI Key HTFNVAVTYILUCF-UHFFFAOYSA-N
Molecular Weight (g/mol) 648.78
PubChem CID 122705989
Formula Weight 648.78
Chemical Name or Material 5,11-Dihydro-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-meth
Grade >98%
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