missing translation for 'onlineSavingsMsg'
Learn More
Learn More
BD Caspase-8
Play role in apoptosis induced by death receptors
Brand: BD 556481
This item is not returnable.
View return policy
Description
Caspases are cysteine proteases that play central role in apoptosis. The caspase family was discovered by searching human cDNA libraries for sequences homologous to ced-3, a C. elegans death gene that is required for normal apoptosis during development
- Fas and tumor necrosis factor receptor type 1 (TNFR1)
- One of its substrates is poly (ADP ribose) polymerase (PARP)
- PARP is an enzyme that is involved in DNA repair and genomic maintenance
- Cleaves PARP from its 116kDa form to 85kDa residual fragment
- The cleavage site in PARP is C-terminal to Asp-216
- Utilized as basis for highly specific caspase-3 substrates such as Ac(N-acetyl)-DEVD-AFC (7-amino-4-trifluoromethylcourmarin) and Ac(N-acetyl)-DEVD-AMC (7-amino-4-methylcoumarin) as well as caspase-3 aldehyde inhibitor Ac-DEVD-CHO
- Format: Purified
Fluorescence quantitation
Specifications
| 0.2mg/mL | |
| Human Caspase-8 Protease Recombinant Protein | |
| -80°C | |
| Recombinant |
| Fluorescence Quantitation | |
| 5μg | |
| Human |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Research use only
Spot an opportunity for improvement?Share a Content Correction