BMPR1A Monoclonal Antibody (4B7B2), Invitrogen™

Description

MA5-17036 targets BMPR1A in indirect ELISA, FACS, IHC and WB applications and shows reactivity with Human samples. The MA5-17036 immunogen is purified recombinant fragment of human BMPR1A (amino acids: 179-378 ) expressed in E. Coli. MA5-17036 detects BMPR1A which has a predicted molecular weight of approximately 60kDa.

BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.