Cytokeratin 14 Monoclonal Antibody (RCK107), Invitrogen™

Description

MA1-06323 detects cytokeratin 14 in human, rat, canine, and porcine samples. MA1-06323 has sucessfully been used in Western blotting, immunocytochemistry and immunohistochemistry. The MA1-06323 immunogen is a cytoskeletal preparation of TR146 epithelial cells. Store at 4oC or in small aliquots at -20oC.

Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. skin) and non-keratinizing cells (ie. mesothelial cells). At least 20 different CKs can be identified. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). Belonging to the type I subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.