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  7. Dorsomorphin dihydrochloride, Tocris Bioscience™

Dorsomorphin dihydrochloride, Tocris Bioscience™

Product Code. 18054882
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Quantity:
10 mg
50 mg
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Description

Potent AMPK inhibitor

Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR (Cat. No. 2840) and Metformin (Cat. No. 2864). Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6), promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro and promotes neural differentiation of hPSCs as part of a chemical cocktail. Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.

Chemical Identifiers

CAS 1219168-18-9
Molecular Formula C24H27Cl2N5O
Molecular Weight (g/mol) 472.414
InChI Key RJDVIJJQKMGPMV-UHFFFAOYSA-N
Synonym dorsomorphin dihydrochloride, dorsomorphin 2hcl, compound c, 4-6-4-2-piperidin-1-yl ethoxy phenyl pyrazolo 1,5-a pyrimidin-3-yl pyridine dihydrochloride, 6-4-2-1-piperidinyl ethoxy phenyl-3-4-pyridinyl-pyrazolo 1,5-a pyrimidine dihydrochloride, 6-4-2-piperidin-1-ylethoxy phenyl-3-pyridin-4-ylpyrazolo 1,5-a pyrimidine;dihydrochloride, 6-4-2-piperidin-1-yl ethoxy phenyl-3-pyridin-4-yl pyrazolo 1,5-a pyrimidine dihydrochloride, dorsomorphin dihydrochlorid, dorsomorphin compound c 2hcl
PubChem CID 49761481
IUPAC Name 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride
SMILES C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl

Specifications

Quantity 10 mg
Formula Weight 472.41
Percent Purity >98%
Chemical Name or Material Dorsomorphin dihydrochloride
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