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DPO-1, Tocris Bioscience™

Product Code. 30001329
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Blocker of KV1.5 channel and IKur current

Blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5). Displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (∽ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.

Chemical Identifiers

CAS 43077-30-1
Molecular Formula C22H29OP
Molecular Weight (g/mol) 340.45
MDL Number MFCD09038567
InChI Key BPCNGVCAHAIZEE-UHFFFAOYNA-N
Synonym dpo-1, neomenthyldiphenylphosphine oxide, +-neomenthyl diphenylphosphine oxide, 1s,2s,5r-5-methyl-2-1-methylethyl cyclohexyl diphenyl-phosphine oxide, diphenyl phosphine oxide-1, dpo-1, needles nmr, 1s,2s,5r-2-isopropyl-5-methylcyclohexyl diphenyl phosphine oxide, 1s,2s,5r-2-isopropyl-5-methylcyclohexyl phenyl phosphoroso benzene, 1s,2s,5r-5-methyl-2-propan-2-yl cyclohexyl oxo diphenyl-lambda∼5∼-phosphane, 1s-1?,2?,5?-5-methyl-2-1-methylethyl cyclohexyl diphenylphosphine oxide
PubChem CID 21678144
IUPAC Name {[5-methyl-2-(propan-2-yl)cyclohexyl](phenyl)phosphoroso}benzene
SMILES CC(C)C1CCC(C)CC1P(=O)(C1=CC=CC=C1)C1=CC=CC=C1

Specifications

Quantity 10 mg
Formula Weight 340.44
Percent Purity >99%
Chemical Name or Material DPO-1
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