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Thermo Scientific™ GeneBLAzer™ LXRβ-UAS-bla HEK 293T Cells
LXR beta-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human Liver-X receptor-beta (LXR beta) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer™UAS-bla HEK 293T cell line.
Brand: Thermo Scientific™ K1699
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Description
LXR beta-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human Liver-X receptor-beta (LXR beta) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer™UAS-bla HEK 293T cell line. GeneBLAzer™UAS-bla HEK 293T cells stably express a beta-lactamase reporter gene under the transcriptional control of an upstream activator sequence (UAS). When an agonist binds to the LBD of the GAL4 (DBD)-LXR beta (LBD) fusion protein, the protein binds to the UAS, resulting in expression of beta-lactamase. Division Arrested (DA) cells are available in two configurations- an Assay Kit (which includes cells and sufficient substrate to analyze 1 x 384-well plate), and a tube of cells sufficient to analyze 10 x 384-well plates. LXR beta-UAS-bla HEK 293T 293 cells are functionally validated for Z' and EC50 concentrations of TO901317. In addition, cells have been tested for assay performance under variable conditions, including DMSO concentration, cell number, stimulation time, and substrate loading time (data available upon request). Additional testing data using alternate stimuli are also available.
Specifications
| DHT | |
| Cell-based beta lactamase reporter gene | |
| LXR beta-UAS-bla HEK 293T cells (K1131) Shipping: Dry Ice Storage: -80°C (liquid nitrogen), Liquid Nitrogen |
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| Nuclear Receptors | |
| Nuclear Receptors | |
| GeneBLAzer™ | |
| HEK 293T Cells | |
| LXR beta, NR1H2, LXRB |
| Cyp Acetate, Spirolactone, OHF | |
| Dividing Cells | |
| Fluorescence, Fluorescent | |
| Human | |
| R1881 | |
| 2 x 106 Cells | |
| BLA (Beta-Lactamase) | |
| Dividing Cells |
For Research Use Only. Not for use in diagnostic procedures.