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Thermo Scientific™ GeneBLAzer™ LXRα-UAS-bla HEK 293T Cells

LXR alpha-UAS-bla HEK 293T 293 cells contain the ligand-binding domain (LBD) of the human Liver-X receptor-alpha(LXR alpha) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer™UAS-bla HEK 293T cell line.

Brand:  Thermo Scientific™ K1692

Product Code. 10465185

  • 10390.00 EUR / Each
Estimated Shipment: 20-01-2025
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Description

Description

LXR alpha-UAS-bla HEK 293T 293 cells contain the ligand-binding domain (LBD) of the human Liver-X receptor-alpha(LXR alpha) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer™UAS-bla HEK 293T cell line. GeneBLAzer™UAS-bla HEK 293T cells stably express a beta-lactamase reporter gene under the transcriptional control of an upstream activator sequence (UAS). When an agonist binds to the LBD of the GAL4 (DBD)-LXR alpha (LBD) fusion protein, the protein binds to the UAS, resulting in expression of beta-lactamase. Division Arrested (DA) cells are available in two configurations- an Assay Kit (which includes cells and sufficient substrate to analyze 1 x 384-well plate), and a tube of cells sufficient to analyze 10 x 384-well plates. LXR alpha-UAS-bla HEK 293T 293 cells are functionally validated for Z' and EC50 concentrations of TO901317. In addition, LXR alpha-UAS-bla HEK 293T 293 cells have been tested for assay performance under variable conditions, including DMSO concentration, cell number, stimulation time, and substrate loading time (data available upon request). Additional testing data using alternate stimuli are also available.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Cholic Acid, Deoxycholic Acid
Cell-based beta lactamase reporter gene
LXR alpha-UAS-bla HEK 293T cells (K1249)

Shipping: Dry Ice
Storage: -80°C (liquid nitrogen), Liquid Nitrogen
Antagonist: (z)-guggulsterone; Primary Agonist: Chenodeoxycholic Acid (CDCA)
Human
LXR alpha-UAS-bla HEK 293T cells (K1249)
Chenodeoxycholic Acid (CDCA)
2 x 106 Cells
BLA (Beta-Lactamase)
Dividing Cells
(z)-guggulsterone
Dividing Cells
Fluorescence, Fluorescent
Nuclear Receptors
Nuclear Receptors
2 x 106
GeneBLAzer™
HEK 293T Cells
LXRA, LXR alpha, NR1H3
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