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Thermo Scientific™ GeneBLAzer™ TRα-UAS-bla HEK 293T Assay Kit

TR alpha-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human Thyroid hormone receptor alpha(TR alpha) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer™UAS-bla HEK 293T cell line.

Brand:  Thermo Scientific™ K1684

Product Code. 10318763

  • 10380.00 EUR / Each
Estimated Shipment: 21-01-2025
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Description

Description

TR alpha-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human Thyroid hormone receptor alpha(TR alpha) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer™UAS-bla HEK 293T cell line. GeneBLAzer™UAS-bla HEK 293T cells stably express a beta-lactamase reporter gene under the transcriptional control of an upstream activator sequence (UAS). When an agonist binds to the LBD of the GAL4 (DBD)-TR alpha (LBD) fusion protein, the protein binds to the UAS, resulting in expression of beta-lactamase. TR alpha-UASbla HEK 293T 293 cells are functionally validated for Z' and EC50 concentrations of T3 Thryoid hormone. In addition, TR alpha-UAS-bla HEK 293T 293 cells have been tested for assay performance under variable conditions, including DMSO concentration, cell number, stimulation time, and substrate loading time (data available upon request). Additional testing data using alternate stimuli are also available.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

9-cis-retinoic acid, TTNPB, CD437, AM 580
Cell-based beta lactamase reporter gene
TR alpha-UAS-bla HEK 293T cells (K1260)

Shipping: Dry Ice
Storage:-80°C (liquid nitrogen)
Fluorescence
TR alpha-UAS-bla HEK 293T cells (K1260)
GeneBLAzer™
BLA (Beta-Lactamase)
Detection Assay Kit
GeneBLAzer™
AGN 193109
Dividing Cells
Primary Agonist: All-trans-retinoic Acid; Antagonists: AGN 193109; Reporter: BLA (Beta-Lactamase)
Nuclear Receptors
All-trans-retinoic Acid
1 Plate
THRA, TR alpha, NR1A1
HEK 293T
Nuclear Receptors
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