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GI 254023X, Tocris Bioscience™
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Quantity:
1 mg
Description
Selective ADAM10 metalloprotease inhibitor; displays over 100-fold higher potency at ADAM10 compared to ADAM17. Blocks constitutive release of IL-6R, CX3CL1 and CXCL16 in cell-based cleavage experiments. Inhibits calcium ionophore-induced betacellulin shedding in IMPE cells. Prevents E-cadherin cleavage in A549 cells. Inhibits ADAM10 mediated neuronal outgrowth of dorsal root ganglion neurons in vitro.
Specifications
Specifications
| CAS | 260264-93-5 |
| Molecular Formula | C21H33N3O4 |
| MDL Number | MFCD19381832 |
| Quantity | 1 mg |
| Synonym | 2r-n-1s-2,2-dimethyl-1-methylamino carbonyl propyl-2-1s-1-n-hydroxyformamido ethyl-5-phenylpentanamide, 2r,3s-3-formylhydroxyamino-2-3-phenyl-1-propyl butanoic acid 1s-2,2-dimethyl-1-methylcarbamoyl-1-propyl amide, bidd:pxr0042, gi254023x hplc, 2r-n-1s-2,2-dimethyl-1-methylcarbamoyl propyl-2-1s-1-n-hydroxyformamido ethyl-5-phenylpentanamide, 2r-n-2s-3,3-dimethyl-1-methylamino-1-oxidanylidene-butan-2-yl-2-1s-1-methanoyl oxidanyl amino ethyl-5-phenyl-pentanamide, 2r-n-2s-3,3-dimethyl-1-methylamino-1-oxobutan-2-yl-2-1s-1-formyl hydroxy amino ethyl-5-phenylpentanamide, r-n-s-3,3-dimethyl-1-methylamino-1-oxobutan-2-yl-2-s-1-n-hydroxyformamido ethyl-5-phenylpentanamide, gi 254023x r-n-s-3,3-dimethyl-1-methylamino-1-oxobutan-2-yl-2-s-1-nhydroxyformamido |
| InChI Key | GHVMTHKJUAOZJP-UHFFFAOYNA-N |
| SMILES | CNC(=O)C(NC(=O)C(CCCC1=CC=CC=C1)C(C)N(O)C=O)C(C)(C)C |
| IUPAC Name | N-[2,2-dimethyl-1-(methylcarbamoyl)propyl]-2-[1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide |
| Molecular Weight (g/mol) | 391.51 |
| PubChem CID | 9952396 |
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