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Tocris Bioscience™ Ibrutinib
Potent and selective BTK inhibitor (IC50= 0.5 nM)
209.00 EUR - 803.00 EUR
Specifications
| Chemical Name or Material | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one |
|---|---|
| CAS | 936563-96-1 |
| Synonym | Agammaglobulinaemia tyrosine kinase, AGMX1, ATKIMD1, B-cell progenitor kinase, BPK, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, dominant-negative kinase-deficient Brutons tyrosine kinase, tyrosine-protein kinase |
| Molecular Formula | C25H24N6O2 |
| Formula Weight | 440.5 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18757926
|
Tocris Bioscience™
6813/10 |
10 mg |
209.00 EUR
10mg |
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|
18716506
|
Tocris Bioscience™
6813/50 |
50 mg |
803.00 EUR
50mg |
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Description
- Selective for BTK against a screening panel of kinase enzymes
- Inhibits autophosphorylation of BTK, phosphorylation of PLCγ, and phosphorylation of ERK (IC50 of 11 nM, 29 nM and 13 nM, respectively)
- Induces cytotoxicity of chronic lymphocytic leukemia (CLL) cells
- Reduces clinical arthritis scores in a mouse model.
Specifications
| 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one | |
| Agammaglobulinaemia tyrosine kinase, AGMX1, ATKIMD1, B-cell progenitor kinase, BPK, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, dominant-negative kinase-deficient Brutons tyrosine kinase, tyrosine-protein kinase | |
| 440.5 |
| 936563-96-1 | |
| C25H24N6O2 | |
| 98% |
Safety and Handling
Recommended Storage : Store at -20°C