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Thermo Scientific Chemicals Itraconazole, 99%
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Itraconazole is an aromatic ether that works as a strong inhibitor of P-glycoproteins and CYP3A4
• Itraconazole also acts as a hedgehog signaling inhibitor and P450 inhibitor
Applications
• Itraconazole can be exhibits antifungal activity against organisms including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis
• Itraconazole may be used to experimentally target the delivery of other molecules, such as plasmids, to cells
Specifications
Specifications
Melting Point | 168.0°C to 170.0°C |
Loss on Drying | 0.5% max. |
Infrared Spectrum | Authentic |
Assay Percent Range | 98.5% min. (HPLC) |
Quantity | 5 g |
Merck Index | 15,5292 |
Solubility Information | Solubility in water: <1mg/mL. Other solubilities: solubility in ethanol: <1mg/mL, solubility in dmso: 4mg/mL |
Formula Weight | 705.64 |
Percent Purity | 99% |
Chemical Name or Material | Itraconazole |
Safety and Handling
- Itraconazole
- Warning
- Acute toxicity Category 4
- Serious eye damage/eye irritation Category 2
- Skin corrosion/irritation Category 2
- Specific target organ toxicity Category 3
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- H335-May cause respiratory irritation.
- H302-Harmful if swallowed.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
- P302+P352-IF ON SKIN: Wash with plenty of water/.
- P312-Call a POISON CENTER/doctor/if you feel unwell.
- P332+P313-If skin irritation occurs: Get medical advice/attention.
- P337+P313-If eye irritation persists: Get medical advice/attention.
RUO – Research Use Only
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