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  8. Ki 20227, Tocris Bioscience™

Ki 20227, Tocris Bioscience™

Product Code. 18085532
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Quantity:
10 mg
50 mg
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Description

c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation

Inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC50 values are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFRβ and c-Kit respectively). Does not inhibit Flt3, EGFR or c-Src. Suppresses osteoclast differentiation and osteolysis in a rat bone metastasis model.

Chemical Identifiers

CAS 623142-96-1
Molecular Formula C24H24N4O5S
Molecular Weight (g/mol) 480.539
InChI Key SHPFDGWALWEPGS-UHFFFAOYSA-N
Synonym 1-4-6,7-dimethoxyquinolin-4-yl oxy-2-methoxyphenyl-3-1-thiazol-2-yl ethyl urea, 1-4-6,7-dimethoxyquinolin-4-yloxy-2-methoxyphenyl-3-1-thiazol-2-yl ethyl urea, 1-4-6,7-dimethoxyquinolin-4-yl oxy-2-methoxyphenyl-3-1-1,3-thiazol-2-yl ethyl urea, pubchem22465, d08bjr, n-4-6,7-dimethoxy-4-quinolinyl o xy-2-methoxyphenyl-n'-1-2-thiazolyl ethyl urea, n-4-6,7-dimethoxy-4-quinolinyl oxy-2-methoxyphenyl-n'-1-2-thiazolyl ethyl urea, n-4-6,7-dimethoxy-4-quinolyl oxy-2-methoxyphenyl-n'-1-1,3-thiazol-2-yl ethyl urea
PubChem CID 9869779
IUPAC Name 1-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-methoxyphenyl]-3-[1-(1,3-thiazol-2-yl)ethyl]urea
SMILES CC(C1=NC=CS1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)OC

Specifications

Quantity 10 mg
Formula Weight 480.54
Percent Purity >97%
Chemical Name or Material Ki 20227
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