missing translation for 'onlineSavingsMsg'
Learn More
Learn More
MGMT (O-methylguanine-DNA methyltransferase) Ab-1 Mouse Monoclonal Antibody, Epredia™
Epredia™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.
Brand: Epredia MS-470-P1
403.04 EUR valid until 2024-12-31
Use promo code "21628" to get your promotional price.
This item is not returnable.
View return policy
Description
Cancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal cross-links at the O-alkylguanine position in DNA. MGMT transfers alkyl adducts from the O-position of guanine in DNA (prior to cross-link formation) to a cysteine residue in its own sequence, thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA-damage it can tolerate. In normal tissues, MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely be drug-resistant.Host Species: Mouse
Clone: MT 3.1
Isotype: IgG1
Species Reactivity: Human. Also reacts weakly with Mouse, Rat and Hamster. Others not known.
Epitope: aa 8-221
Immunogen: Purified recombinant human MGMT protein
Molecular Weight: 25kDa
Positive Control: Raji cells, Colon CA
Cellular Localization: Nuclear and cytoplasmic
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Flow Cytometry
Note:
USA: RUO; Int'l: RUO
Specifications
| MGMT (O-methylguanine-DNA methyltransferase) Ab-1 | |
| Monoclonal | |
| 200μg/mL | |
| Mouse | |
| 500 μL | |
| Enzyme | |
| Hamster, Human, Mouse, Rat | |
| IgG1 |
| Immunohistochemistry (Paraffin), Western Blot | |
| MT 3.1 | |
| Unconjugated | |
| Purified recombinant human MGMT protein | |
| RUO | |
| Primary | |
| Concentrated |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- APD Primary Antibody Products, Antibody Diluent
Signal Word
- Danger
Hazard Category
- Respiratory sensitiser Category 1
- Skin sensitiser Category 1
Hazard Statement
- H317-May cause an allergic skin reaction.
- H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary Statement
- P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
- P284-¢In case of inadequate ventilation! wear respiratory protection.
- P272-Contaminated work clothing should not be allowed out of the workplace.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P302+P352-IF ON SKIN: Wash with plenty of water/and soap.
- P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
- P363-Wash contaminated clothing before reuse.
Supplemental information
- MIXTURE LIST-Contains : Albumins, blood serum, Sodium azide, Antibody (Animal)
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction