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Tocris Bioscience™ LDN 193189 dihydrochloride
Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs
144.00 EUR - 1135.00 EUR
Specifications
| Chemical Name or Material | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride |
|---|---|
| CAS | 1435934-00-1 |
| Synonym | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride |
| Target | BMP and Other Activin Receptor Inhibitors |
| Molecular Formula | C25H22N60.2 HCl |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18707806
|
Tocris Bioscience™
6053/10 |
10 mg |
300.00 EUR
10mg |
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|
18787766
|
Tocris Bioscience™
6053/50 |
50 mg |
1135.00 EUR
50mg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
|
18075802
|
Tocris Bioscience™
6053/1 |
1 mg |
144.00 EUR
1mg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
LDN 193189 dihydrochloride is a potent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Exhibits >200-fold selectivity for BMP signaling over TGF-β signaling. Also exhibits selectivity over AMPK, PDGFR and MAPK signaling. Promotes neural induction of hPSCs in combination with SB 431542 (Cat.No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat.No. 1614), SU 5402 (Cat.No.3300), CHIR 99021 (Cat.No. 4423) and DAPT (Cat.No. 2634).LDN 193189 synthesized to Ancillary Material Grade also available.
For more information about how LDN 193189 dihydrochloride may be used, see our protocols: Generation of β cells from hPSCs, Generating Midbrain Dopaminergic Neurons from hPSCs, Accelerated Induction of Cortical Neurons from hiPSCs .
Specifications
| 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride | |
| 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride | |
| C25H22N60.2 HCl | |
| Solid | |
| Bioactive Small Molecule |
| 1435934-00-1 | |
| BMP and Other Activin Receptor Inhibitors | |
| 479.4 | |
| Orange | |
| 98% |
Safety and Handling
Recommended Storage : Store at -20°C
For Research Use Only.