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Tocris Bioscience™ NR 162
Potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor
Brand: Tocris Bioscience™ 7572/10
220.30 EUR valid until 2024-12-16
Use promo code "21630" to get your promotional price.
This item is not returnable.
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Description
NR 162 is a potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor (IC50 = 80 nM); it exhibits no significant activity against related kinases MERTK, AXL and ABL1 and ~ 47-fold selectivity over TYRO3 (IC50 = 3.8 μM). NR 162 targets the unique pocket created by CASK GFG motif; it is a type-I inhibitor which stabilizes the active state of CASK without affecting the scaffolding function. NR 162 induces cell death in actively differentiating cells of the P19 neuronal differentiation model. NR 162 shows no toxicity in differentiated cells, or in cancer cells.Specifications
| 4-(Cyclopentylamino)-2-((2,5-dibromo-4-methylbenzyl)amino)-N-(3-(2-oxooxazolidin-3-yl)propyl)pyrimidine-5-carboxamide | |
| 10 mg | |
| C24H30Br2N6O3 |
| 2755241-73-5 | |
| CaM Kinase Inhibitors |