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PD-1 Monoclonal Antibody (7A11B1), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA515780
This item is not returnable.
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Description
A suggested positive control is PD-1 recombinant protein.
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "e;danger signals"e; such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.Specifications
PD-1 | |
Monoclonal | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
Q02242, Q15116 | |
Pdcd1 | |
A ∽150 amino acid recombinant protein from near the amino terminus of mouse PD-1 | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG1 |
Immunohistochemistry, Western Blot | |
7A11B1 | |
Unconjugated | |
Pdcd1 | |
CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2 | |
Mouse | |
Protein A | |
RUO | |
18566, 301626, 5133 | |
-20°C | |
Liquid |