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PD 176252, Tocris Bioscience™
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Quantity:
10 mg
Description
Non-peptide gastrin-releasing peptide receptor (GRP-R, BB2) and neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 0.17 and 1.0 nM for BB1 and BB2 respectively). Inhibits proliferation of rat C6 glioma cells (IC50 = 2 μM) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 μM).
Specifications
Specifications
| CAS | 204067-01-6 |
| Molecular Formula | C32H36N6O5 |
| Quantity | 10 mg |
| Synonym | d0i5cs, gtpl626, s-n-1-5-methoxy-2-pyridinyl cyclohexyl methyl-a-methyl-a--4-nitrophenyl amino carbonyl amino-1h-indole-3-propanamide, 1h-indole-3-propanamide, n-1-5-methoxy-2-pyridinyl cyclohexyl methyl-alpha-methyl-alpha-4-nitrophenyl amino carbonyl amino-, alphas, 1h-indole-3-propanamide, n-1-5-methoxy-2-pyridinyl cyclohexyl methyl-alpha-methyl-alpha-4-nitrophenyl amino carbonyl amino-, s, 2s-3-1h-indol-3-yl-n-1-5-methoxypyridin-2-yl cyclohexyl methyl-2-methyl-2-4-nitrophenyl carbamoylamino propanamide, 2s-3-1h-indol-3-yl-n-1-5-methoxypyridin-2-yl cyclohexyl methyl-2-methyl-2-4-nitrophenyl carbamoyl amino propanamide, s-3-1h-indol-3-yl-n-1-5-methoxy-pyridin-2-yl-cyclohexylmethyl-2-methyl-2-3-4-nitro-phenyl-ureido-propionamide, s-n-1-5-methoxy-2-pyridinyl cyclohexyl methyl-?-methyl-?--4-nitrophenyl amino carbonyl amino-1h-indole-3-propanamide |
| InChI Key | NNFUWNLENRUDHR-HKBQPEDESA-N |
| SMILES | CC(CC1=CNC2=CC=CC=C21)(C(=O)NCC3(CCCCC3)C4=NC=C(C=C4)OC)NC(=O)NC5=CC=C(C=C5)[N+](=O)[O-] |
| IUPAC Name | (2S)-3-(1H-indol-3-yl)-N-[[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl]-2-methyl-2-[(4-nitrophenyl)carbamoylamino]propanamide |
| Molecular Weight (g/mol) | 584.677 |
| PubChem CID | 9829828 |
| Formula Weight | 584.67 |
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