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Thermo Scientific™ pH Gradient Buffer Concentrates
Descrizione
Robust reproducible gradients that are applicable to a wide range of MAbs and ready to use with existing LC columns and systems, without the need to formulate mobile phases.
Obtain fast and highly robust, reproducible HPLC gradients using Thermo Scientific™ CX-1 pH Gradient Buffers. Simple to optimize and easily automated, these buffers are applicable for HPLC separation of the majority of monoclonal antibody (mAb) biotherapeutics drugs. CX-1 pH Gradient Buffers are ready to use with existing HPLC columns without the need to formulate mobile phases. The CX-1 buffers save time in method development, facilitate method transfer to QA/QC for a wide range of mAb charge variants through a generic HPLC-based approach to mAb characterization, and do not require time-consuming mobile phase adjustments.
pH buffer solutions can be used to generate highly reproducible, linear pH gradients in cation exchange chromatography.
- Robust, reproducible gradients
- Predict biomolecule pH
- Simple method optimization
- Easily automated
- Applicable to the majority of MAbs
Unlike traditional cation exchange chromatography using salt gradients, it is possible to predict the pH and the expected retention of the charge variants and use a narrow pH range to get a higher resolution separation.
Specifica
Specifica
| Description | CX-1 pH Gradient Buffer B |
| For Use With (Equipment) | LC Columns and Systems |
| Type | CX-1 pH Gradient Buffer B |
| Volume (Metric) | 125 mL |
| pH | 10.2 |
| Quantity | 125 mL |
| Standard Concentration | 10X |
| Product Line | Thermo Scientific |
Sicurezza e movimentazione
- 125ML CX-1 pH Gradient Buffer B (pH 10.2)
- Warning
- Serious eye damage/eye irritation Category 2
- Skin corrosion/irritation Category 2
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- P264-Wash thoroughly after handling.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P302+P352-IF ON SKIN: Wash with plenty of water/.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P332+P313-If skin irritation occurs: Get medical advice/attention.
- P337+P313-If eye irritation persists: Get medical advice/attention.
- MIXTURE LIST-Contains : sodium hydroxide, chloroform
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