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Phospho-c-Abl (Tyr245) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA512532
This item is not returnable.
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Description
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns c-Abl into an oncogene. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for c-Abl. In chronic myelogenous leukemia and a subset of acute lymphoblastic leukemias, the c-Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The c-Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-ABL potentially regulates DNA repair by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.![TRUSTED_SUSTAINABILITY](/content/dam/fishersci/glyphs/Sustain_Badge.png)
Specifications
Phospho-c-Abl (Tyr245) | |
Polyclonal | |
Unconjugated | |
ABL1 | |
Abelson murine leukemia oncogene; Abelson murine leukemia viral (v-abl) oncogene homolog 1; abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Abl; Abl 1 antib; ABL proto-oncogene 1, non-receptor tyrosine kinase; Abl1; ABL2; ABLL; AI325092; ARG; B30; bcr/abl; bcr/c-abl oncogene protein; c-ABL; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; c-ABL1; E430008G22Rik; JTK7; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; RP11-83J21.1; Tyrosine kinase ARG; tyrosine-protein kinase ABL1; v-abl; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene 1; v-abl Abelson murine leukemia viral oncogene homolog 1 | |
Rabbit | |
Antigen affinity chromatography, Protein A | |
RUO | |
11350, 25 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
0.5 mg/mL | |
PBS with 0.09% sodium azide | |
P00519, P00520 | |
ABL1 | |
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y245 of human ABL1 | |
400 μL | |
Primary | |
Human, Mouse | |
Antibody | |
Ig |