Phospho-C5AR1 (Ser334) Polyclonal Antibody, Invitrogen™

Description

Phospho-C5AR1 (Ser334) Polyclonal Antibody detects endogenous levels of C5AR1 only when phosphorylated at Ser334.

C5AR1 is an C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. C5AR1 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, C5AR1 stimulates chemotaxis, granule enzyme release and superoxide anion production. C5a is likely a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with C5AR1 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.