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Thermo Scientific™ SMPT (4-succinimidyloxycarbonyl-alpha-methyl-α(2-pyridyldithio)toluene)
Crosslink amines to sulfhydryls with this crosslinker containing NHS-ester and pyridyldithiol groups at the ends of an aromatic, 6-atom (11.2A) spacer arm.
Brand: Thermo Scientific™ 21558
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Description
Thermo Scientific™ Pierce SMPT is a long-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form strong (hindered) yet cleavable (reducible) disulfide bonds with cysteine sulfhydryls.
Highlights:
- Contains a hindered disulfide bond; forms stable immunotoxins
- In vitro, an SMPT conjugate was as effective as conjugates formed with SPDP and 2-iminothiolane
- Reactive groups: NHS ester and pyridyldisulfide
- Reactive toward: amino and sulfhydryl groups
Specifications
| Amine-Sulfhydryl | |
| SMPT | |
| No | |
| Upon receipt store desiccated at 4°C. | |
| Ambient | |
| Chemical Labeling | |
| NHS Ester, Pyridyldisulfide | |
| Powder | |
| DMF, DMSO | |
| No |
| By Thiols | |
| 388.46 | |
| 11.2 Å | |
| Yes | |
| Pierce™ | |
| Heterobifunctional | |
| Medium (10 to 30 Å) | |
| 50 mg | |
| Standard | |
| Crosslinker |
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Product Title
For Research Use Only. Not for use in diagnostic procedures.
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