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PIGR Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

145.00 EUR - 410.00 EUR

Specifications

Antigen PIGR
Concentration 0.49 mg/mL
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16861565
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Proteintech
22024-1-AP-20UL
20 μL
145.00 EUR
20µL
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16851565
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Proteintech
22024-1-AP-150UL
150 μL
410.00 EUR
150µL
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Description

Description

Polymeric IgA and IgM is produced and secreted by B cells in the lamina propria, which is beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors, also designated pIgRs, are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium. pIgR associates with secreted dimeric IgA and IgM molecules. During transcellular transport of these Ig polymers, pIgR undergoes proteolytic cleavage to generate a fragment called secretory component (SC), polymeric immunoglobulin receptor or poly-IG receptor. When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during the transcytosis process. SC and the pIgR are crucial for proper mucosal immunity where they represent a molecular chaperone for polymeric Igs to remain intact and enter into body fluids. The human SC (pIgR) gene maps to chromosome 1q31-q41 and encodes a 764 amino acid protein. The receptor contains five units with homology to the variable (V) units of immunoglobulins and a transmembrane region that shares homology to certain immunoglobulin variable regions.
Specifications

Specifications

PIGR
Immunohistochemistry (Paraffin)
Unconjugated
Rabbit
Human
P01833
5284
PIGR Fusion Protein Ag16876
Primary
-20°C
PIGR
0.49 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
PIGR, Poly Ig receptor
PIGR
IgG
Antigen Affinity Chromatography
Antibody
Videos
SDS
Documents

Documents

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