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  6. 18768946

Tocris Bioscience™ Pyr 10

Selective TRPC3 inhibitor

Brand:  Tocris Bioscience™ 6941/50

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Product Code. 18768946

  • 682.00 EUR / 50mg

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Description

Description

Pyr 10 is a TRPC3 (transient receptor potential canonical 3) channel inhibitor (IC50 = 0.72 μM for TRPC3 mediated calcium entry in vitro), which displays approximately 18-fold selectivity for TRPC3-mediated receptor operated calcium entry (ROCE) over STIM1/Orai1-mediated store operated calcium entry (SOCE). Pyr 10 inhibits NFATc3 activation and inhibits proliferation of rat ventricular cardiac fibroblasts.
Specifications

Specifications

N-[4-[3,5-bis(Trifluoromethyl)-1 H-pyrazol-1-yl]phenyl]-4-methylbenzenesulfonamide
50 mg
C18H13F6N3O2S
1315323-00-2
TRPC Channel Blockers
0.98
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