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Tocris Bioscience™ RECTAS

IKBKAP pre-mRNA splicing modulator

Brand:  Tocris Bioscience™ 7679/50

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Product Code. 18707026

  • 774.00 EUR / 50mg

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Description

Description

RECTAS (rectifier of aberrant splicing) is a pre-mRNA splicing modulator of the IKBKAP (inhibitor of κ light polypeptide gene enhancer in B-cells, kinase complex associated protein) gene. It corrects aberrant IKBKAP splicing in vitro in cellular models of familial dysautonomia and in vivo in transgenic mice. In combination with Phenylbutyric acid (Cat. No. 2682), RECTAS rescues PARK7 aberrant splicing and neuronal cell loss in a midbrain organoid model of familial Parkinson's disease. Orally bioavailable and brain penetrant.
Specifications

Specifications

2-Chloro-N-(2-furanylmethyl)-7 H-purin-6-amine
50 mg
C10H8ClN5O
101862-47-9
DNA, RNA and Protein Synthesis Compounds
0.98
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