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Tocris Bioscience™ RU.521
Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)
253.00 EUR - 1015.00 EUR
Specifications
| Chemical Name or Material | 3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone |
|---|---|
| CAS | 2262452-06-0 |
| Target | Synthase/Synthetase Inhibitors |
| Molecular Formula | C19H12Cl2N4O3 |
| Purity | 0.98 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18736205
|
Tocris Bioscience™
7904/10 |
10 mg |
253.00 EUR
10mg |
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|
18766005
|
Tocris Bioscience™
7904/50 |
50 mg |
1015.00 EUR
50mg |
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Description
RU.521 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor (Kd = 36.2 nM; IC50 values are 0.11 μM and 2.94 μM against m-cGAS and h-cGAS, respectively). RU.521 suppresses dsDNA-activated reporter activity but not 5'ppp-HP20 RNA or murine IFN-β-induced IFN-β1-dependent gene expression. RU.521 reduces constitutive expression of type I interferon in primary macrophages from a mouse model of Aicardi-Gouti?res syndrome. Pretreatment of chimeric antigen receptor (CAR) redirected T cells with RU.521 increases efficiency of virus-free gene editing by improving cell viability and CAR integration in cell line.Specifications
| 3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone | |
| Synthase/Synthetase Inhibitors | |
| 0.98 |
| 2262452-06-0 | |
| C19H12Cl2N4O3 |
Safety and Handling
Recommended Storage : Store at -20°C