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  5. Tocris Bioscience™ RU.521

Tocris Bioscience™ RU.521

Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)

253.00 EUR - 1015.00 EUR

Specifications

Chemical Name or Material 3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone
CAS 2262452-06-0
Target Synthase/Synthetase Inhibitors
Molecular Formula C19H12Cl2N4O3
Purity 0.98
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Product Code Brand Quantity Price Quantity & Availability  
18736205
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Tocris Bioscience™
7904/10 		10 mg
253.00 EUR
10mg
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18766005
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Tocris Bioscience™
7904/50 		50 mg
1015.00 EUR
50mg
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Description

Description

RU.521 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor (Kd = 36.2 nM; IC50 values are 0.11 μM and 2.94 μM against m-cGAS and h-cGAS, respectively). RU.521 suppresses dsDNA-activated reporter activity but not 5'ppp-HP20 RNA or murine IFN-β-induced IFN-β1-dependent gene expression. RU.521 reduces constitutive expression of type I interferon in primary macrophages from a mouse model of Aicardi-Gouti?res syndrome. Pretreatment of chimeric antigen receptor (CAR) redirected T cells with RU.521 increases efficiency of virus-free gene editing by improving cell viability and CAR integration in cell line.
Specifications

Specifications

3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone
Synthase/Synthetase Inhibitors
0.98
2262452-06-0
C19H12Cl2N4O3
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Safety and Handling

Recommended Storage : Store at -20°C

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