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  8. SB 225002, Tocris Bioscience™

SB 225002, Tocris Bioscience™

Product Code. 18084762
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Quantity:
50 mg
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This item is not returnable. View return policy

Description

Potent and selective CXCR2 antagonist

Potent and selective CXCR2 chemokine receptor antagonist (IC50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GROα-mediated calcium mobilization in HL60 cells (IC50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo. Inhibits HIV replication in lymphocytes and macrophages.

Chemical Identifiers

CAS 182498-32-4
Molecular Formula C13H10BrN3O4
Molecular Weight (g/mol) 352.14
MDL Number MFCD00954637
InChI Key MQBZVUNNWUIPMK-UHFFFAOYSA-N
Synonym 1-2-bromophenyl-3-2-hydroxy-4-nitrophenyl urea, n-2-bromophenyl-n'-2-hydroxy-4-nitrophenyl urea, 3-2-bromophenyl-1-2-hydroxy-4-nitrophenyl urea, n-2-hydroxy-4-nitrophenyl-n′-2-bromophenyl urea, d0e9bu, d0f6wv, d0t2ad, gtpl833, n-2-hydroxy-4-nitrophenyl-n'-2-bromophenyl urea, p 1-6-hydroxymethylpterin-p 2-5'-adenosyl diphosphate
PubChem CID 3854666
IUPAC Name 3-(2-bromophenyl)-1-(2-hydroxy-4-nitrophenyl)urea
SMILES OC1=C(NC(=O)NC2=CC=CC=C2Br)C=CC(=C1)[N+]([O-])=O

Specifications

Quantity 50 mg
Formula Weight 352.14
Percent Purity >99%
Chemical Name or Material SB 225002
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