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Thioperamide, Tocris Bioscience™

Product Code. 30000709
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

H3 antagonist; also H4 inverse agonist

Potent histamine H3 and H4 antagonist/inverse agonist. Ki values are 25 and 27 nM for human recombinant H3 and H4 receptors respectively. Blocks eosinophil shape change (IC50 = 1.4 μM) and chemotaxis (IC50 = 519 nM) induced by histamine. Freely crosses the blood-brain barrier.

Chemical Identifiers

CAS 106243-16-7
Molecular Formula C19H28N4O4S
Molecular Weight (g/mol) 408.517
InChI Key WUYMIKDBRCCYGE-UHFFFAOYSA-N
Synonym 1-piperidinecarbothioamide, n-cyclohexyl-4-1h-imidazol-4-yl-, 2z-2-butenedioate 1:1
PubChem CID 53393972
IUPAC Name but-2-enedioic acid;N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide
SMILES C1CCC(CC1)NC(=S)N2CCC(CC2)C3=CN=CN3.C(=CC(=O)O)C(=O)O

Specifications

Quantity 10 mg
Formula Weight 292.44
Percent Purity >99%
Chemical Name or Material Thioperamide
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