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  7. Zoniporide dihydrochloride, Tocris Bioscience™

Zoniporide dihydrochloride, Tocris Bioscience™

Product Code. 18023852
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Selective NHE1 inhibitor

Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+ uptake in vitro (IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.

Chemical Identifiers

CAS 241799-10-0
Molecular Formula C17H18Cl2N6O
Molecular Weight (g/mol) 393.272
InChI Key ARZNPJAGKWHEHT-UHFFFAOYSA-N
Synonym zoniporide dihydrochloride, 1-quinolin-5-yl-5-cyclopropyl-1h-pyrazole-4-carbonyl guanidine dihydrochloride
PubChem CID 22267855
IUPAC Name 5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide;dihydrochloride
SMILES C1CC1C2=C(C=NN2C3=CC=CC4=C3C=CC=N4)C(=O)N=C(N)N.Cl.Cl

Specifications

Quantity 10 mg
Formula Weight 393.27
Percent Purity >99%
Chemical Name or Material Zoniporide dihydrochloride
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