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  6. 18015692

ACET, Tocris Bioscience™

Product Code. 18015692
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Quantity:
10 mg
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Description

Potent kainate antagonist; displays selectivity for GluK1-containing receptors

Potent and selective GluK1 (formerly GluR5) containing kainate receptor antagonist (IC50 = 7 nM) that displays selectivity over GluK2 (formerly GluR6) containing kainate, NMDA, AMPA and group I mGlu receptors. Reversibly blocks induction of NMDA receptor-independent long term potentiation (LTP) in vitro at nanomolar concentrations.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Specifications

CAS 936095-50-0
Molecular Formula C20H21N3O6S
Quantity 10 mg
Synonym (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-5-phenylthiophene-3-yl-methyl)-5-methylpyrimidine-2, 4-dione
InChI Key OAAMYRWMIRGBQF-UHFFFAOYSA-N
SMILES CC1CN(C(=O)N(C1=O)CC2=C(SC(=C2)C3=CC=CC=C3)C(=O)O)CC(C(=O)O)N
IUPAC Name 3-[[3-(2-amino-2-carboxyethyl)-5-methyl-2,6-dioxo-1,3-diazinan-1-yl]methyl]-5-phenylthiophene-2-carboxylic acid
Molecular Weight (g/mol) 431.463
PubChem CID 118797384
Formula Weight 429.45
Percent Purity >98%
Chemical Name or Material ACET
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