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Human AMPK A2/B1/G1, GST Tag, His Tag Recombinant Protein
Human AMPK A2/B1/G1, GST Tag, His Tag Recombinant Protein
Brand: Invitrogen PV4674
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Description
AMP-activated protein kinase (AMPK) is a heterotrimeric complex that acts as a sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulating metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. An impairment in fuel metabolism that occurs in obesity is a factor leading to Type 2 diabetes. The insulin resistance associated with type 2 diabetes is most profound at the level of skeletal muscle, the primary site of glucose and fatty acid utilization. Activation of AMPK is of interest for the treatment of type 2 diabetes.
Specifications
| NP_0062243.2 I NP_006244.2 I NP_002724.1 | |
| 91.4/ 57.8/ 41.7 kDa | |
| AMPK A2/B1/G1 | |
| Human | |
| GST Tag, His Tag | |
| Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical binding/kinetic | |
| Dry Ice | |
| GST (N-Terminal)⁄GST (N-Terminal)⁄His (N-Terminal) | |
| Baculovirus | |
| Recombinant, Full Length | |
| Serine/Threonine Kinases |
| Kinase Assay | |
| 10 μg | |
| CAMKL Kinase Family | |
| Recombinant | |
| Storage Buffer: 50 mM Tris, pH 7.5, 150 mM NaCl, 0.02% Triton X-100, 0.5 mM EDTA, 2 mM DTT, 50% Glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws. |
|
| Ser⁄Thr Kinases: CAMK Group | |
| LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™, Omnia™ Bulk Substrate | |
| AMPK (A2/B1/G1) | |
| Kinases & Inhibitors | |
| Liquid | |
| Signal Transduction |