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Tocris Bioscience™ AZD 7762 hydrochloride

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2

Brand:  Tocris Bioscience™ 5199/50

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Product Code. 18786228

  • 795.00 EUR / 50mg

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Description

Description

AZD 7762 hydrochloride is a potent and selective ATP-competitive inhibitor of Chk1 and Chk2 (IC50 vales are 5 nM for both kinases); displays at least >10 fold selectivity over a panel of 164 kinases. Potentiates cytotoxicity of DNA-damaging agents. Active in vivo. Also improves efficiency of CRISPR-Cpf1-mediated genome editing in hPSC lines (2.7-fold at 1 μM).
Specifications

Specifications

>98%
AZD 7762 hydrochloride
AZD 7762 hydrochloride
50 mg
398.88
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