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BMS 299897, Tocris Bioscience™ Product Code.: 18095032
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BMS 299897, Tocris Bioscience™

Product Code. 18095032
10 mg
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Quantity:
10 mg
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Product Code. 18095032

Brand: Tocris Bioscience 2870/10

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Description

Potent γ-secretase inhibitor

Orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Exhibits no Notch toxicity. Brain penetrant.
TRUSTED_SUSTAINABILITY

Specifications

CAS 290315-45-6
Molecular Formula C24H21ClF3NO4S
Quantity 10 mg
Synonym 2-1r-1-4-chlorophenyl sulfonyl 2,5-difluorophenyl amino ethyl-5-fluoro-benzenebutanoic acid, 2-1r-1-4-chlorophenyl sulfonyl 2,5-difluorophenyl amino ethyl-5-fluorobenzenebutanoic acid, 4-2-1r-1-n-2,5-difluorophenyl 4-chlorobenzenesulfonamido ethyl-5-fluorophenyl butanoic acid
InChI Key IZAOBRWCUGOKNH-OAHLLOKOSA-N
SMILES CC(C1=C(C=C(C=C1)F)CCCC(=O)O)N(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
IUPAC Name 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid
Molecular Weight (g/mol) 511.94
PubChem CID 11249248
Formula Weight 511.94
Percent Purity >98%
Chemical Name or Material BMS 299897
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