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Dihydro-β-erythroidine hydrobromide, Tocris Bioscience™

Product Code. 18094072
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Quantity:
10 mg
50 mg
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Description

α4β2, muscle type and Torpedo nAChR antagonist

Dihydro-β-erythroidine hydrobromide is a member of the Erythrina alkaloids, it is a competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α4 receptor subunit (IC50 values are 0.19 and 0.37 μM for α4β4 and α4β2 receptors, respectively). Antagonizes behavioral effects of nicotine in vivo. Dihydro-β-erythroidine blocks excitation of striatal GABAergic neurons, which completely suppress polysynaptic inhibition between striatal cholinergic interneurons. Dihydro-β-erythroidine hydrobromide has antidepressive-like effects in mice (forced swim and mouse suspension). Orally bioavailable

Chemical Identifiers

CAS 29734-68-7
Molecular Formula C16H22BrNO3
Molecular Weight (g/mol) 356.26
InChI Key GFIGWAJEIMHJJB-LINSIKMZSA-N
Synonym dihydro-beta-erythroidine hydrobromide, unii-ns1u03gc05, 2s,13bs-2-methoxy-2,3,5,6,8,9,10,13-octahydro-1h,12h-benzo i pyrano 3,4-g indolizin-12-one hydrobromide, dh?e, dihydro-?-erythroidine hydrobromide, 3, a-1,6-didehydro-14,17-dihydro-3-methoxy-16 15h-oxaerythrinan-15-one hydrobromide, 3beta-1,6-didehydro-14,17-dihydro-3-methoxy-16 15h-oxaerythrinan-15-one hydrobromide
PubChem CID 11957537
SMILES COC1CC=C2CCN3C2(C1)C4=C(CC3)COC(=O)C4.Br

Specifications

Quantity 50 mg
Formula Weight 356.26
Percent Purity >98%
Chemical Name or Material Dihydro-β-erythroidine hydrobromide
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