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FK 888, Tocris Bioscience™

Product Code. 18044292
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Quantity:
10 mg
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This item is not returnable. View return policy

Description

High affinity NK1 antagonist

Selective, high affinity tachykinin NK1 receptor antagonist (Ki = 0.69 nM) that displays 320-fold selectivity for human over rat NK1 receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.

Specifications

CAS 138449-07-7
Molecular Formula C36H36N4O4
Quantity 10 mg
Synonym d05ukk, n 2-4-hydroxy-1-1-methyl-1h-indol-3-yl carbonyl-l-prolyl-n-methyl-n-phenylmethyl-3-2-naphthyl-l-alaninamide, l-alaninamide, trans-4-hydroxy-1-1-methyl-1h-indol-3-yl carbonyl-l-prolyl-n-methyl-3-2-naphthalenyl-n-phenylmethyl, 2s,4r-4-hydroxy-1-1-methylindole-3-carbonyl-n-2s-1-methyl-phenylmethyl amino-3-naphthalen-2-yl-1-oxopropan-2-yl pyrrolidine-2-carboxamide, 2s,4r-n-2s-1-benzyl methyl amino-3-naphthalen-2-yl-1-oxopropan-2-yl-4-hydroxy-1-1-methylindole-3-carbonyl pyrrolidine-2-carboxamide, 4r-4-hydroxy-1-1-methyl-1h-indol-3-yl carbonyl-l-prolyl-n-methyl-3-2-naphthalenyl-n-phenylmethyl-l-alaninamide, l-alaninamide, 4r-4-hydroxy-1-1-methyl-1h-indol-3-yl carbonyl-l-prolyl-n-methyl-3-2-naphthalenyl-n-phenylmethyl
InChI Key BFNKQTIJVFGCKQ-PDJGWCFMSA-N
SMILES CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O
IUPAC Name (2S,4R)-N-[(2S)-1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-4-hydroxy-1-(1-methylindole-3-carbonyl)pyrrolidine-2-carboxamide
Molecular Weight (g/mol) 588.708
PubChem CID 107967
Formula Weight 588.69
Percent Purity >98%
Chemical Name or Material FK 888
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