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Gibco™ Human TPO (Thrombopoietin) Recombinant Protein, PeproTech®
Recombinant Protein
83.75 EUR - 4445.00 EUR
Specifications
| Accession Number | P40225 |
|---|---|
| For Use With (Application) | ELISA, Functional Assay, Western Blot |
| Formulation | protein with no preservative |
| Gene ID (Entrez) | 7066 |
| Molecular Weight (g/mol) | 18.6 kDa |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
17859962
|
Gibco™
300-18-100UG |
100 μg |
886.00 EUR
100µg |
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|
17811113
|
Gibco™
300-18-10UG |
10 μg |
203.00 EUR
10µg |
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|
17830433
|
Gibco™
300-18-1MG |
1 mg |
4445.00 EUR
1mg |
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|
17881713
|
Gibco™
300-18-250UG |
250 μg |
1556.00 EUR
250µg |
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|
17850343
|
Gibco™
300-18-2UG |
2 μg |
83.75 EUR
2µg |
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|
17871713
|
Gibco™
300-18-500UG |
500 μg |
2665.00 EUR
500µg |
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|
17811813
|
Gibco™
300-18-50UG |
50 μg |
534.00 EUR
50µg |
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Description
Recombinant Human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.Specifications
| P40225 | |
| protein with no preservative | |
| 18.6 kDa | |
| E. coli | |
| <1 EU/ μg | |
| Thrombopoietin | |
| The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg | |
| Recombinant | |
| -20°C | |
| Lyophilized |
| ELISA, Functional Assay, Western Blot | |
| 7066 | |
| Human TPO (Thrombopoietin) | |
| RUO | |
| C-mpl ligand; Megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; megakaryocyte stimulating factor; Mgdf; MKCSF; ML; MPL ligand; Mpllg; MSA; Myeloproliferative leukemia virus oncogene ligand; prepro-thrombopoietin; TDH2A; THCYT1; THPO; Thrombopoietin; thyroid microsomal antigen; thyroid peroxidase; thyroperoxidase; Tpo; TPX | |
| THPO | |
| Unconjugated | |
| SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL | |
| E. coli | |
| ≥ 98% by SDS-PAGE gel and HPLC analyses. |
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Product Title
Gibco™ Human TPO (Thrombopoietin) Recombinant Protein, PeproTech®