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  7. Thermo Scientific Chemicals Indomethacin

Thermo Scientific Chemicals Indomethacin

Product Code. 15472202
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Quantity:
5 g
25 g
100 g
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This item is not returnable. View return policy

Description

Indomethacin, CAS # 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID).

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release

• Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics

• Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation

Applications

• Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions

• Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 53-86-1
Molecular Formula C19H16ClNO4
Molecular Weight (g/mol) 357.79
InChI Key CGIGDMFJXJATDK-UHFFFAOYSA-N
Synonym indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
PubChem CID 3715
ChEBI CHEBI:49662
IUPAC Name 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
SMILES CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

Specifications

Melting Point 155.0°C
Loss on Drying 0.5% max. (100°C, 2 h, 5 mm Hg)
Infrared Spectrum Authentic
Quantity 25 g
Formula Weight 357.79
Percent Purity ≥97.5% (HPLC)
Chemical Name or Material Indomethacin

Safety and Handling

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Product Identifier
  • Indomethacin
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 1
  • Skin sensitiser Category 1
  • Reproductive toxicity Category 1B
 Hazard Statement
  • H300-Fatal if swallowed.
  • H317-May cause an allergic skin reaction.
  • H360FD-May damage fertility. May damage the unborn child.
 Precautionary Statement
  • P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
  • P330-Rinse mouth.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P201-Obtain special instructions before use.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only

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