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Tocris Bioscience™ Ivosidenib
Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)
Brand: Tocris Bioscience™ 7761/10
129.58 EUR valid until 2024-12-16
Use promo code "21630" to get your promotional price.
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Description
Ivosidenib is a potent inhibitor of mutant isocitrate dehydrogenase enzyme 1 (mIDH1), with activity against a variety of mutant IDH1 enzymes (IC50 range = 5-19 nM). Reduces intracellular 2-HG (Cat. No. 6122) by 96% at 0.5 μM. Increases sensitivity of melanoma to Temozolomide (Cat. No. 2706) in vivo and inhibits wild-type IDH1 in low magnesium and low nutrient levels. Ivosidenib also inhibits growth of tumors in cell and animal models of pancreatic cancer and inhibits invasion and migration of chondrosarcoma cells in vitro.Specifications
| (2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide | |
| 10 mg | |
| C28H22ClF3N6O3 |
| 1448347-49-6 | |
| Isocitrate Dehydrogenase 1/IDH1 |