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Tocris Bioscience™ Ivosidenib
Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)
165.00 EUR - 609.00 EUR
Specifications
| Chemical Name or Material | (2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
|---|---|
| CAS | 1448347-49-6 |
| Target | Isocitrate Dehydrogenase 1/IDH1 |
| Molecular Formula | C28H22ClF3N6O3 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18736926
|
Tocris Bioscience™
7761/10 |
10 mg |
165.00 EUR
10mg |
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|
18798656
|
Tocris Bioscience™
7761/50 |
50 mg |
609.00 EUR
50mg |
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Description
Ivosidenib is a potent inhibitor of mutant isocitrate dehydrogenase enzyme 1 (mIDH1), with activity against a variety of mutant IDH1 enzymes (IC50 range = 5-19 nM). Reduces intracellular 2-HG (Cat. No. 6122) by 96% at 0.5 μM. Increases sensitivity of melanoma to Temozolomide (Cat. No. 2706) in vivo and inhibits wild-type IDH1 in low magnesium and low nutrient levels. Ivosidenib also inhibits growth of tumors in cell and animal models of pancreatic cancer and inhibits invasion and migration of chondrosarcoma cells in vitro.Specifications
| (2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide | |
| 1448347-49-6 | |
| Isocitrate Dehydrogenase 1/IDH1 | |
| C28H22ClF3N6O3 |
Safety and Handling
Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.