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Ki-67 Monoclonal Antibody (4A1), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA515525

503.14 EUR valid until 2024-11-29
Use promo code "21683" to get your promotional price.


Product Code. 11315493

  • 530.00 EUR / 100µL

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Description

Description

MA5-15525 targets KI67 in indirect ELISA, IHC applications and shows reactivity with Human samples. The MA5-15525 immunogen is synthetic peptide corresponding to aa (CEDLAGFKELFQTPG) of human KI67, conjugated to KLH. MA5-15525 detects KI67 which has a predicted molecular weight of approximately 358kDa.

Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Ki-67
Monoclonal
Conc. Not Determined
ascites with 0.03% sodium azide
P46013
Mki67
Synthetic peptide corresponding to aa (CEDLAGFKELFQTPG) of human KI67, conjugated to KLH.
RUO
4288
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
ELISA, Immunocytochemistry, Immunohistochemistry
4A1
Unconjugated
Mki67
antigen identified by monoclonal antibody Ki 67; antigen identified by monoclonal antibody Ki-67; Antigen identified by monoclonal antibody Ki-67 homolog; Antigen KI-67; Antigen KI-67 homolog; antigen KI-67; proliferation marker protein Ki-67; antigen KI-67-like; cb31; D630048A14Rik; I79_022666; Ki67; Ki-67; KIA; LOW QUALITY PROTEIN: proliferation marker protein Ki-67; marker of proliferation Ki-67; MIB-; MIB-1; Mki67; PPP1R105; Proliferation marker protein Ki-67; proliferation-related Ki-67 antigen; protein phosphatase 1, regulatory subunit 105; RP11-380J17.2; sb:cb31; si:ch211-250b22.7; unnamed protein product; wu:fa11g09; wu:fb57a07; wu:fi14e05
Mouse
100 μL
Primary
Human
Antibody
IgG2b
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