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L-748,337, Tocris Bioscience™ Product Code.: 30001390
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L-748,337, Tocris Bioscience™

Product Code. 30001390
10 mg
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Quantity:
10 mg
50 mg
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Product Code. 30001390

Brand: Tocris Bioscience 2760/10

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Description

Selective β3 antagonist

Competitive β3-adrenoceptor antagonist that displays selectivity over β1 and β2 receptors (Ki values are 4.0, 204 and 390 nM for β3-, β2- and β1-adrenoceptors respectively). Inhibits cAMP accumulation in response to isoproterenol (IC50 = 6 nM). Reduces iNOS expression, attenuates nitric oxide-induced cell proliferation and induces apoptosis in a melanoma cell line.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 244192-94-7
Molecular Formula C26H31N3O5S
Molecular Weight (g/mol) 497.61
InChI Key AWIONHVPTYTSHZ-DEOSSOPVSA-N
Synonym n-3-2s-2-hydroxy-3-2-4-phenylsulfonyl amino phenyl ethyl amino propoxy phenyl methyl-acetamide, d03vhk, n-3-2s-2-hydroxy-3-2-4-phenylsulfonylamino phenyl ethylamino propoxy phenyl methyl acetamide
PubChem CID 10028830
IUPAC Name N-[[3-[(2S)-3-[2-[4-(benzenesulfonamido)phenyl]ethylamino]-2-hydroxypropoxy]phenyl]methyl]acetamide
SMILES CC(=O)NCC1=CC(=CC=C1)OCC(CNCCC2=CC=C(C=C2)NS(=O)(=O)C3=CC=CC=C3)O

Specifications

Quantity 10 mg
Formula Weight 497.61
Percent Purity >98%
Chemical Name or Material L-748, 337
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