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M3258, MedChemExpress

MedChemExpress M3258 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor.

Brand:  Medchem Express HY-111790

Encompass_Preferred

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Product Code. 16417247

  • 544.05 EUR / 5mg

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Description

Description

M3258 exerts high biochemical (IC50=3.6 nM) and cellular (IC50=3.4 nM) potency against the LMP7 subunit. M3258 shows strong antitumor efficacy in multiple myeloma xenograft models. M3258 leads to a significant and prolonged suppression of tumor LMP7 activity and ubiquitinated protein turnover and the induction of apoptosis in multiple myeloma cells.
Specifications

Specifications

M3258
White
C17H20BNO5
DMSO : 250 mg/mL (759.51 mM; Need ultrasonic)
329.16
98.0%
Solid
2285330-15-4
Research
5 mg
O=C(N[C@@H](CC1=COC2=C1C=CC=C2)B(O)O)[C@H]3[C@@H]4CC[C@@H](O4)C3
329.16
Research
Cancer-Kinase/protease
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