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NSD2 Monoclonal Antibody (CL1063), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA524621

370.68 EUR valid until 2025-03-29
Use promo code "24111" to get your promotional price.

Product Code. 15769270

  • 556.00 EUR / 100µL

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Description

Description

Immunogen sequence: SANGKTPSCE VNRECSVFLS KAQLSSSLQE GVMQKFNGHD ALPFIPADKL KDLTSRVFNG EPGAHDAKLR FESQEMKGIG TPPNTTPIKN GSPEIKLKIT KTYMNGKPLF ESSICGD Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%. Binds to an epitope located within the peptide sequence ALPFIPADKL as determined by overlapping synthetic peptides.

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
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NSD2 Monoclonal Antibody (CL1063), Invitrogen™ > 100 μL; Unconjugated

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