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Phospho-MECP2 (Ser80) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA5104679
320.68 EUR valid until 2025-03-29
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Description
Antibody detects endogenous levels of MeCP2 only when phosphorylated at Ser80.
MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Specifications
| Phospho-MECP2 (Ser80) | |
| Polyclonal | |
| Unconjugated | |
| Mecp2 | |
| 1500041B07Rik; AUTSX3; D630021H01Rik; DKFZp686A24160; Mbd5; MECP2; MeCp-2 protein; methyl CpG binding protein 2; methyl-CpG binding protein 2; methyl-CpG-binding protein 2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; testis tissue sperm-binding protein Li 41a; WBP10 | |
| Rabbit | |
| sequential chromatography | |
| RUO | |
| 17257, 29386, 4204 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P51608, Q00566, Q9Z2D6 | |
| Mecp2 | |
| A synthesized peptide derived from human MECP2(Accession P51608), corresponding to amino acid residues around phosphorylated Ser80. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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Product Title
Phospho-MECP2 (Ser80) Polyclonal Antibody, Invitrogen™ > 100 μL; Unconjugated
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