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Thermo Scientific Chemicals SB 225002

A potent, selective and competitive antagonist of the G-protein coupled receptor CXCR2

134.00 EUR - 243.00 EUR

Chemical Identifiers

CAS 182498-32-4
Molecular Formula C13H10BrN3O4
Synonym 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
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Thermo Scientific Chemicals
J65387.#0 		5 mg This item is currently unavailable or has been discontinued.
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Thermo Scientific Chemicals
J65387.MA 		10 mg
243.00 EUR
10mg
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Description

Description

SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels. Further studies suggest that SB 225002 decreases the expression of vascular endothelial growth factor, inducible NOS (NO synthase), and Cox-2 (cyclooxygenase-2 proteins) in colon tissue.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Specifications

Chemical Identifiers

182498-32-4
C13H10BrN3O4
1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea

Specifications

Yellow
A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2
C13H10BrN3O4
1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
Soluble to 100mM in DMSO and to 50mM in ethanol
Solid
-30°C to -10°C
182498-32-4
352.10g/mol
Moisture Sensitive
Signal Transduction Reagent
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Recommended Storage : Store at -20°C; Store under Nitrogen

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RUO – Research Use Only

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