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Tocris Bioscience™ Withaferin A
Inhibits NF-κB activation
Brand: Tocris Bioscience™ 2816/1
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Description
Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Withaferin A inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo, prevents NF-κB activation by inhibiting activation of IKKβ and inhibits chymotrypsin-like activity of the 20S proteasome. In an animal model of Huntington's disease (HD), Withaferin A delays disease progression and increases lifespan; in a cellular model it suppresses aggregation of mutant huntingtin, activates HSF1 and induces Hsp70 chaperone expression.
Specifications
| >98% | |
| 1 mg | |
| 470.6 |
| Store at -20°C | |
| Withaferin A | |
| Withaferin A |
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Product Title
Tocris Bioscience™ Withaferin A > 1mg
For Research Use Only
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